Fig. 6

The miR-15 family members regulate the progress of hepatic fibrosis by following ways: (1) miR-16 targets HGF and Smad7 to promote TGF-β/Smad signaling pathway; (2) miR-16 inhibits cell proliferation by targeting CD1; (3) miR-195 downregulates cyclin E1 to inhibit cell proliferation; (4) miR-15b and miR-16b promote apoptosis by targeting Bcl-2