Fig. 4

The miR-34 family members regulate hepatic fibrosis which is induced by chronic liver injury via following ways: (1) miR-34a targets ACSL1 and PPARγ to promote the activation of HSCs; (2) miR-34c targets PPARγ to change the phenotype of HSCs; (3) in hepatocyte, miR-34a inhibits apotosis by downregulating CASP2 and SIRT1. (4) miR-34a participates in cell remodeling by increasing the level of MMP2 and MMP9