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Fig. 2 | Cell & Bioscience

Fig. 2

From: The roles of microRNA families in hepatic fibrosis

Fig. 2

The miR-29 family members regulate the progress of hepatic fibrosis by following ways: (1) miR-29a targets HDAC4 to inhibit the activation of qHSCs; (2) miR-29b targets AKT3 and PI3KR1, then induces cell apoptosis; (3) miR-29a inhibits PDGF-C and IGF-1 to suppress PI3K/AKT signaling pathway; (4) miR-29b inhibits ECM maturation and ECM accumulation by targeting HSP47, LOX and COLIα1, respectively

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