From: APOBEC3B, a molecular driver of mutagenesis in human cancers
Cancer type | Discovery | Model | References |
---|---|---|---|
Breast cancer | Expression of APOBEC3B is increased in breast tumors and cell lines. Breast TCGA tumors have a more prevalent APOBEC3B mutation than is expected | Human tissue samples. In vitro, human cell lines | |
HER2-enriched subtype of breast cancer has a significantly higher frequency of mutations associated with APOBEC3B than other breast cancer subtypes | TCGA | [60] | |
APOBEC3B leads to drug resistance in breast cancer and APOBEC3B-dependent tumor evolvability may serve as a effective target to improve efficacies of anti-cancer therapies | Human tissue samples | ||
APOBEC3B depletion in an ER+Â breast cancer cell line results in prolonged tamoxifen response | Xenograft model | [66] | |
Gastric cancer | APOBEC3B expression was higher in gastric cancer tissues than that in normal tissues and APOBEC3B overexpression indicates the unfavorable prognosis of the patients with gastric cancer | Human tissue samples | |
Chondrosarcoma | APOBEC3B was overexpressed in chondrosarcoma tissues, and APOBEC3B deficiency caused slight apoptosis in the chondrosarcoma cells | Human tissue samples. In vitro, human cell lines | |
Hepatocellular carcinoma | APOBEC3B was the only APOBEC3 family member significantly overexpressed in hepatocellular carcinoma (HCC) tissues and may be a potential factor contributing to suppression of tumor growth in HCC | Human tissue samples. In vitro, human cell lines | [69] |
APOBEC3B is a potential factor contributing to suppression of tumor growth in HCC | In vitro, human cell lines | [70] | |
Renal cancer | Renal clear-cell carcinomas showed statistically notable up-regulation of APOBEC3B | Human tissue samples | |
Colorectal cancer | APOBEC3B was overexpressed in colorectal cancer tissues | Human tissue samples | |
Prostate cancer | Prostate carcinomas showed statistically marked up-regulation of APOBEC3B | Human tissue samples | |
Cervix cancer | APOBEC3B was overexpressed in cervix cancer tissues | Human tissue samples | [8] |
Bladder cancer | APOBEC3B was overexpressed in bladder cancer tissues | Human tissue samples | |
Lung cancer | The APOBEC3B expression is elevated obviously in non-small cell lung cancer (NSCLC) tissues and the overexpression of APOBEC3B was correlated with unfavorable prognosis | Human tissue samples | |
The tumor/normal ratio of APOBEC3B mRNA levels was not different within the sexuality, age, smoking status, epidermal growth factor receptor (EGFR), kirsten rat sarcoma viral oncogene (KRAS) mutation and pathological stages | Human tissue samples | [75] | |
Head and neck | The mRNA level of APOBEC3B were significantly higher in cancer tissues than in the corresponding noncancerous esophageal mucosae | Human tissue samples | |
APOBEC3B mRNA expression was significantly higher in oral squamous cell carcinomas (OSCC), compared to non-cancerous oral tissues | Human tissue samples | [77] | |
Ovarian cancer | APOBEC3B may paly a potential role in serous ovarian cancer genomic instability | Human tissue samples. In vitro, human cell lines | [78] |