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Table 1 Overexpression of APOBEC3B in cancers

From: APOBEC3B, a molecular driver of mutagenesis in human cancers

Cancer type

Discovery

Model

References

Breast cancer

Expression of APOBEC3B is increased in breast tumors and cell lines. Breast TCGA tumors have a more prevalent APOBEC3B mutation than is expected

Human tissue samples. In vitro, human cell lines

[8, 48, 64]

HER2-enriched subtype of breast cancer has a significantly higher frequency of mutations associated with APOBEC3B than other breast cancer subtypes

TCGA

[60]

APOBEC3B leads to drug resistance in breast cancer and APOBEC3B-dependent tumor evolvability may serve as a effective target to improve efficacies of anti-cancer therapies

Human tissue samples

[62, 65]

APOBEC3B depletion in an ER+ breast cancer cell line results in prolonged tamoxifen response

Xenograft model

[66]

Gastric cancer

APOBEC3B expression was higher in gastric cancer tissues than that in normal tissues and APOBEC3B overexpression indicates the unfavorable prognosis of the patients with gastric cancer

Human tissue samples

[8, 62, 67]

Chondrosarcoma

APOBEC3B was overexpressed in chondrosarcoma tissues, and APOBEC3B deficiency caused slight apoptosis in the chondrosarcoma cells

Human tissue samples. In vitro, human cell lines

[8, 68]

Hepatocellular carcinoma

APOBEC3B was the only APOBEC3 family member significantly overexpressed in hepatocellular carcinoma (HCC) tissues and may be a potential factor contributing to suppression of tumor growth in HCC

Human tissue samples. In vitro, human cell lines

[69]

APOBEC3B is a potential factor contributing to suppression of tumor growth in HCC

In vitro, human cell lines

[70]

Renal cancer

Renal clear-cell carcinomas showed statistically notable up-regulation of APOBEC3B

Human tissue samples

[8, 71]

Colorectal cancer

APOBEC3B was overexpressed in colorectal cancer tissues

Human tissue samples

[8, 72]

Prostate cancer

Prostate carcinomas showed statistically marked up-regulation of APOBEC3B

Human tissue samples

[8, 72]

Cervix cancer

APOBEC3B was overexpressed in cervix cancer tissues

Human tissue samples

[8]

Bladder cancer

APOBEC3B was overexpressed in bladder cancer tissues

Human tissue samples

[8, 73]

Lung cancer

The APOBEC3B expression is elevated obviously in non-small cell lung cancer (NSCLC) tissues and the overexpression of APOBEC3B was correlated with unfavorable prognosis

Human tissue samples

[8, 74]

The tumor/normal ratio of APOBEC3B mRNA levels was not different within the sexuality, age, smoking status, epidermal growth factor receptor (EGFR), kirsten rat sarcoma viral oncogene (KRAS) mutation and pathological stages

Human tissue samples

[75]

Head and neck

The mRNA level of APOBEC3B were significantly higher in cancer tissues than in the corresponding noncancerous esophageal mucosae

Human tissue samples

[8, 76]

APOBEC3B mRNA expression was significantly higher in oral squamous cell carcinomas (OSCC), compared to non-cancerous oral tissues

Human tissue samples

[77]

Ovarian cancer

APOBEC3B may paly a potential role in serous ovarian cancer genomic instability

Human tissue samples. In vitro, human cell lines

[78]