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Fig. 2 | Cell & Bioscience

Fig. 2

From: Plant genome editing with TALEN and CRISPR

Fig. 2

TALEN and CRISPR-Cas9. a A TALEN is composed of two monomers with each containing a TALE DNA binding domain and a FokI nuclease domain. Fok1 dimerizes to create a double-strand break. b CRISPR-Cas9 is a two-component system composed of Cas9 and a gRNA. Once Cas9 finds a PAM site, if the gRNA binds to the DNA, a double break occurs three base pairs upstream the PAM

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