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Fig. 2 | Cell & Bioscience

Fig. 2

From: Phosphorylation of LSD1 by PLK1 promotes its chromatin release during mitosis

Fig. 2

The Polo-box domains of PLK1 mediate its interaction with LSD1. a Domain structure of PLK1. PLK1 encodes a polypeptide of 603 AAs. Its amino terminus (1-330 AAs) contains the kinase domain, while its carboxyl terminus (330-CT) harbors two Polo boxes. b Carboxyl terminus of PLK1 mediated its interaction with LSD1. HA-LSD1 and wild-type FLAG-PLK1 or its truncation mutants were transiently co-expressed in 293T cells, total cell lysates were harvested 48 h after transfection and subjected to immunoprecipitation followed by immunoblotting with antibodies as indicated

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