Table 1 Known cellular functions of FANCA

DNA damage response

 Within the FA core complex

Part of A-G20 subcomplex, essential for the ubiquitination of FANCD2

[35]

Intrinsically binds with ds and ssDNA, and RNA

[37]

Phosphorylated at S1149, crucial for complex activity

[40]

Involved in R-loop resolution

[35, 78]

Promotes double strand break repair through homologous. Recombination and single strand annealing

[68, 106]

 Out of the FA core complex

Regulates MUS81–EME1 incision activity at ICL

[38]

Interacts with and regulates XPF’s incision activity at both 5′ and 3′ of ICL

[90, 92]

SH3 mediated FANCA αIISP interaction stabilizes αIISP

[90, 101, 102]

Promotes FEN1 endonuclease activity

[103]

Others

 Oxidative stress mitigation

Enhances cell survival in pro-oxidant conditions

[120, 121]

Oxidative stress induced FANCA/BRG1/promoter complex protects antioxidant defense gene

[130]

 Mitotic stress mitigation

Involved in the maintenance of normal spindle assembly

[142]

T351 phosphorylation by NEK2 may plays a role in preserving centrosome integrity

[144]

N terminus interacts with CENP-E and regulates chromosome alignment

[147]

 Cell migration and motility

Modulates CXCR5 neddylation through an unknown mechanism and further stimulates cell migration and motility

[150]

Direct and indirect transcriptional regulation through HES1, potential in promoting EMT

[151, 152]