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Table 1 Known cellular functions of FANCA

From: Maintenance of genome stability by Fanconi anemia proteins

Pathway Molecular action Reference
DNA damage response
 Within the FA core complex Part of A-G20 subcomplex, essential for the ubiquitination of FANCD2 [35]
Intrinsically binds with ds and ssDNA, and RNA [37]
Phosphorylated at S1149, crucial for complex activity [40]
Involved in R-loop resolution [35, 78]
Promotes double strand break repair through homologous. Recombination and single strand annealing [68, 106]
 Out of the FA core complex Regulates MUS81–EME1 incision activity at ICL [38]
Interacts with and regulates XPF’s incision activity at both 5′ and 3′ of ICL [90, 92]
SH3 mediated FANCA αIISP interaction stabilizes αIISP [90, 101, 102]
Promotes FEN1 endonuclease activity [103]
Others
 Oxidative stress mitigation Enhances cell survival in pro-oxidant conditions [120, 121]
Oxidative stress induced FANCA/BRG1/promoter complex protects antioxidant defense gene [130]
 Mitotic stress mitigation Involved in the maintenance of normal spindle assembly [142]
T351 phosphorylation by NEK2 may plays a role in preserving centrosome integrity [144]
N terminus interacts with CENP-E and regulates chromosome alignment [147]
 Cell migration and motility Modulates CXCR5 neddylation through an unknown mechanism and further stimulates cell migration and motility [150]
Direct and indirect transcriptional regulation through HES1, potential in promoting EMT [151, 152]