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Fig. 1 | Cell & Bioscience

Fig. 1

From: Maintenance of genome stability by Fanconi anemia proteins

Fig. 1

Interstrand crosslink sensing by the Fanconi anemia pathway. a The CMG helicase encounters ICL damage at the replication fork. b FANCM could be the primary factor in recognizing the interstrand crosslink upon replication folk stall. After damage verification presumably by FANCA, assembly of the FA core complex on the ICL site provokes the ubiquitin ligase activity of FANCL and results in monoubiquitination of FANCD2–FANCI complex, which further recruits downstream nucleases, polymerases, and DSB repair factors for the procession and repair of ICL

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