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Fig. 3 | Cell & Bioscience

Fig. 3

From: Small GTPase Arl6 controls RH30 rhabdomyosarcoma cell growth through ciliogenesis and Hedgehog signaling

Fig. 3

Arl6 and Hedgehog pathway is deregulated in ciliated RMS. a Representative images of anti-acetylated tubulin (red) staining in RD and RH30 cell lines. RMS cells were treated with 2% HS for 48 h before fixation for ciliogenesis. b Q-PCR quantification of Arl6 (left), Gli1 (right) in RD and RH30 cells, as well as in normal skeletal muscles (SKM). The data represents the mean ± SEM of three independent experiments. **P < 0.01 vs. RD. IHC staining of Arl6 (c, d) or Gli1 (e, f) in normal muscle and RMS from Ptch1+/− mouse. g, h Staining of primary cilia (red) and nuclei (blue) in the same tissues from cf

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