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Fig. 6 | Cell & Bioscience

Fig. 6

From: Downregulation of long non-coding RNA H19 promotes P19CL6 cells proliferation and inhibits apoptosis during late-stage cardiac differentiation via miR-19b-modulated Sox6

Fig. 6

Sox6 reversed the proliferation and antiapoptosis effects of H19 knockdown on P19CL6 cells. a CCK-8 assay indicated shH19 boosted the viability of P19CL6 cells at day 8 and day 10, and pcDNA-Sox6 reversed the effect. b Cell cycle assay found that shH19 increased the percentage of cells in the S phase at day 8 and 10, whereas pcDNA-Sox6 attenuated the effect. (c and d) The rate of apoptosis and caspase-3 activity were significantly decreased in cells treated with shH19 at day 8 and 10, and pcDNA-Sox6 overturned the effect. *P < 0.05, **P < 0.01, ***P < 0.001

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