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Fig. 1 | Cell & Bioscience

Fig. 1

From: Downregulation of long non-coding RNA H19 promotes P19CL6 cells proliferation and inhibits apoptosis during late-stage cardiac differentiation via miR-19b-modulated Sox6

Fig. 1

The expression levels of GATA4, Nkx-2.5, α-MHC, MLC-2v and H19 are significantly upregulated and miR-19b was downregulated at indicated time points. a mRNA levels of early cardiac-specific markers (GATA4 and Nkx-2.5α-MHC) were increased significantly in P19CL6 cells at day 4 and 6. b Protein levels of GATA4 and Nkx-2.5α-MHC were augmented significantly in P19CL6 cells at day 4 and 6. c mRNA levels of cardiac contractile protein genes (α-MHC and MLC-2v) were increased significantly in P19CL6 cells at day 10 and 12. d Protein levels of α-MHC and MLC-2v were elevated significantly in P19CL6 cells at day 10 and 12. e Level of H19 was augmented significantly from day 8 to day 12. f Level of miR-19b was dropped significantly from day 8 to day 12. **P < 0.01, ***P < 0.001

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