MAP4K4: an emerging therapeutic target in cancer

Cell & Bioscience

Table 3 MAP4K4-specific small-molecule inhibitors

Name	Type	Specificity	Biological/Preclinical disease model	Clinical trial	Ref.
GNE-495	KI	MAP4K4	Angiogenesis in mouse model	NA	[12, 53]
GNE-220	KI	MAP4K4	Angiogenesis in mouse model	NA	[12]
PF-6260933	KI	MAP4K4	Vascular inflammation, atherosclerosis	NA	[18, 54]
4-Hydroxy-2-pyridone	KI	MAP4K4	Neuroblastoma cell	NA	[55]

ISSN: 2045-3701