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Table 3 MAP4K4-specific small-molecule inhibitors

From: MAP4K4: an emerging therapeutic target in cancer

Name Type Specificity Biological/Preclinical disease model Clinical trial Ref.
GNE-495 KI MAP4K4 Angiogenesis in mouse model NA [12, 53]
GNE-220 KI MAP4K4 Angiogenesis in mouse model NA [12]
PF-6260933 KI MAP4K4 Vascular inflammation, atherosclerosis NA [18, 54]
4-Hydroxy-2-pyridone KI MAP4K4 Neuroblastoma cell NA [55]
  1. KI kinase inhibitor, NA not available
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