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Table 3 MAP4K4-specific small-molecule inhibitors
| Name | Type | Specificity | Biological/Preclinical disease model | Clinical trial | Ref. |
|---|---|---|---|---|---|
| GNE-495 | KI | MAP4K4 | Angiogenesis in mouse model | NA | [12, 53] |
| GNE-220 | KI | MAP4K4 | Angiogenesis in mouse model | NA | [12] |
| PF-6260933 | KI | MAP4K4 | Vascular inflammation, atherosclerosis | NA | [18, 54] |
| 4-Hydroxy-2-pyridone | KI | MAP4K4 | Neuroblastoma cell | NA | [55] |
