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Table 2 Current information on MAP4K4 in cancer

From: MAP4K4: an emerging therapeutic target in cancer

Tumor type/cell line studied

Patient prognosis correlation

Manipulation of MAP4K4

Year of publication

Ref.

Method

Functional consequences

Suggested downstream effector

Tumors of the digestive system

 Colorectal cancer tissues and cell line

MAP4K4 expression was reversely correlated with overall survival and lymph node metastasis

NA

NA

NA

2010

[30]

 Colorectal cancer tissues and cell line

NA

siRNA knockdown

Cell proliferation↓, colony formation↓, G0/G1 arrest and apoptosis↑

MAPK/JNK, MDM2

2015

[41]

 Gastric cancer cells

NA

siRNA knockdown

cell proliferation↓, G1 phase arrest, apoptosis↑ and invasion↓

Notch2, Notch3, Hes1

2015

[38]

 Hepatocellular carcinoma

MAP4K4 expression was a negative predictor of overall survival and early recurrence rate

shRNA knockdown

S phase arrest, apoptosis↑

MAPK/JNK, NF-κB, TLRs

2011

[31]

 Hepatocellular carcinoma cell line

NA

siRNA knockdown

Cell invasion↓

MMP-2, MMP-9, NF-κB

2010

[40]

 Pancreatic cancer tissues and cell lines

NA

siRNA knockdown

Cell proliferation↓, colony formation↓, invasion↓, G1 arrest, apoptosis↓, chemosensitivity↑ and xenograft tumor growth↓

NA

2013

[37]

 Stage II pancreatic ductal adenocarcinoma

MAP4K4 expression was associated with poor overall and recurrence-free survival

NA

NA

NA

2008

[32]

Head and neck cancer

 Larynx carcinoma cell line

NA

siRNA knockdown

Cell migration↓ and invasion↓

JNK

2015

[35]

 Lung cancer

 Lung adenocarcinoma

MAP4K4 expression was associated with shorter overall and recurrence-free survival

NA

NA

NA

2012

[33]

 Lung adenocarcinoma cell lines

NA

shRNA knockdown

Cell apoptosis↑

Survivin

2014

[36]

Gynecologic cancer

 Ovarian carcinoma cell line

NA

siRNA knockdown

Cell motility↓

MAPK/JNK

2006

[39]

Genitourinary cancer

 Prostate cancer

MAP4K4 was associated with time to biochemical failure

NA

NA

NA

2014

[34]

Tumor of the central nervous system

 Glioblastoma cell line

NA

shRNA knockdown

Cell migration↓ and invasion↓

NA

2013

[26]

Mesenchymal tumor

 Kaposi’s sarcoma

NA

siRNA knockdown

Reactivation of Kaposi’s sarcoma herpesvirus and cell invasion↓

COX-2, MMP-7, MMP-13

2013

[42]

Others

 60 cell lines from NCI tumor panel

NA

Kinase-inactive mutation

Anchorage-independent growth↓, cell invasion↓, cell adhesion↑ and spreading rates↑

STAT3

2003

[9]

  1. NA not available