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Table 2 Current information on MAP4K4 in cancer

From: MAP4K4: an emerging therapeutic target in cancer

Tumor type/cell line studied Patient prognosis correlation Manipulation of MAP4K4 Year of publication Ref.
Method Functional consequences Suggested downstream effector
Tumors of the digestive system
 Colorectal cancer tissues and cell line MAP4K4 expression was reversely correlated with overall survival and lymph node metastasis NA NA NA 2010 [30]
 Colorectal cancer tissues and cell line NA siRNA knockdown Cell proliferation↓, colony formation↓, G0/G1 arrest and apoptosis↑ MAPK/JNK, MDM2 2015 [41]
 Gastric cancer cells NA siRNA knockdown cell proliferation↓, G1 phase arrest, apoptosis↑ and invasion↓ Notch2, Notch3, Hes1 2015 [38]
 Hepatocellular carcinoma MAP4K4 expression was a negative predictor of overall survival and early recurrence rate shRNA knockdown S phase arrest, apoptosis↑ MAPK/JNK, NF-κB, TLRs 2011 [31]
 Hepatocellular carcinoma cell line NA siRNA knockdown Cell invasion↓ MMP-2, MMP-9, NF-κB 2010 [40]
 Pancreatic cancer tissues and cell lines NA siRNA knockdown Cell proliferation↓, colony formation↓, invasion↓, G1 arrest, apoptosis↓, chemosensitivity↑ and xenograft tumor growth↓ NA 2013 [37]
 Stage II pancreatic ductal adenocarcinoma MAP4K4 expression was associated with poor overall and recurrence-free survival NA NA NA 2008 [32]
Head and neck cancer
 Larynx carcinoma cell line NA siRNA knockdown Cell migration↓ and invasion↓ JNK 2015 [35]
 Lung cancer
 Lung adenocarcinoma MAP4K4 expression was associated with shorter overall and recurrence-free survival NA NA NA 2012 [33]
 Lung adenocarcinoma cell lines NA shRNA knockdown Cell apoptosis↑ Survivin 2014 [36]
Gynecologic cancer
 Ovarian carcinoma cell line NA siRNA knockdown Cell motility↓ MAPK/JNK 2006 [39]
Genitourinary cancer
 Prostate cancer MAP4K4 was associated with time to biochemical failure NA NA NA 2014 [34]
Tumor of the central nervous system
 Glioblastoma cell line NA shRNA knockdown Cell migration↓ and invasion↓ NA 2013 [26]
Mesenchymal tumor
 Kaposi’s sarcoma NA siRNA knockdown Reactivation of Kaposi’s sarcoma herpesvirus and cell invasion↓ COX-2, MMP-7, MMP-13 2013 [42]
Others
 60 cell lines from NCI tumor panel NA Kinase-inactive mutation Anchorage-independent growth↓, cell invasion↓, cell adhesion↑ and spreading rates↑ STAT3 2003 [9]
  1. NA not available