Table 1 Summary of MAP4K4 knockout mouse models

Whole-body knockout

Embryonic lethality

[11]

Whole-body-inducible knockout

Reduced plasma glucose levels and enhanced insulin sensitivity

[19]

Skin conditional knockout

Aberrant wound repair and epidermal cell migration defects

[13]

T cell-specific knockout

Systemic inflammation and type 2 diabetes

[16]

Endothelial cell-specific knockout

Embryonic lethality

[12]

Endothelial cell-specific inducible knockout

Protected from vascular inflammation and atherosclerosis

[18]