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Table 1 Summary of MAP4K4 knockout mouse models

From: MAP4K4: an emerging therapeutic target in cancer

Tissue/cell type Phenotype Ref.
Whole-body knockout Embryonic lethality [11]
Whole-body-inducible knockout Reduced plasma glucose levels and enhanced insulin sensitivity [19]
Skin conditional knockout Aberrant wound repair and epidermal cell migration defects [13]
T cell-specific knockout Systemic inflammation and type 2 diabetes [16]
Endothelial cell-specific knockout Embryonic lethality [12]
Endothelial cell-specific inducible knockout Protected from vascular inflammation and atherosclerosis [18]