Fig. 7

Roxarsone affects the growth pattern of B16–F10 xenografts. The xenograft tumors were excised; paraffin sections were created and stained with H&E staining and histologically analyzed (×100). Representative images (of at least five mice per group) are shown for the A PBS control and B–D 1, 5, and 25 mg/kg roxarsone groups designed as Control, Low Rox, Middle Rox and High Rox. Clustered growth with centrally located blood vessels (indicated by the arrow) was observed in the roxarsone groups, but this was rarely observed in the PBS control group