Fig. 6
Roxarsone promotes the growth of B16–F10 xenografts growth. B16–F10 tumor cells (1 × 105) were implanted subcutaneously into the external surface of the right ribs of mice. After 7 days, the mice were intragastrically administered 0, 1, 5 or 25 mg/kg roxarsone once a day for another 7 days; the corresponding groups are designed as the Control, Low Rox, Middle Rox and High Rox groups respectively. A Tumor size was measured using vernier calipers, and tumor volume was calculated as described in “Methods” section. Data represent the average tumor volumes at the given day after implantation. Significant growth was observed in all the groups (p < 0.05, n = 6), and significant differences were observed between treatment groups and the PBS control group (*p < 0.05, as determined by two-way ANOVA). B B16–F10 xenografts were excised and weighed. The results represent the mean ± SD values of six mice. *p < 0.05, **p < 0.01 vs. the PBS control