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Fig. 1 | Cell & Bioscience

Fig. 1

From: Histone acetyl transferase GCN5 promotes human hepatocellular carcinoma progression by enhancing AIB1 expression

Fig. 1

GCN5 expression is frequently up-regulated in human HCC tissues and cell lines. a Western blot analysis of GCN5 protein expression in a set of 31 human HCC specimens and surrounding non-tumorous tissues. N non-tumorous tissue, T tumor tissue. Asterisk indicates GCN5 up-regulated HCC specimens. Hash indicates GCN5 down-regulated HCC specimens. β-actin was used as a loading control. b Relative mRNA levels of GCN5 were up-regulated in HCC specimens. GCN5 mRNA levels in 41 pairs of specimens (tumorous and surrounding non-tumorous liver tissues) were measured by real-time PCR. Relative quantification was achieved by normalization to GAPDH. *p < 0.05. c Protein expression of GCN5 was up-regulated in HCC cell lines (MHCC97H, SK-Hep-1, HepG2, and Huh-7) compared with hepatocyte cell line L-O2. All cell lines were cultured in DMEM. β-actin was used as a loading control

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