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Table 3 Neurological clinical phenotypes associated with ZIKV DEGs

From: Bioinformatic analysis reveals the expression of unique transcriptomic signatures in Zika virus infected human neural stem cells

Disease Gene symbol Gene name
Microcephaly DYRK1A Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
MCPH1 Microcephalin 1
CASK Calcium/calmodulin-dependent serine protein kinase (MAGUK family)
PHGDH Phosphoglycerate dehydrogenase
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2
ASPM Asp (abnormal spindle) homolog, microcephaly associated
CENPJ Centromere protein J
CEP152 Centrosomal protein 152 kDa
SLC25A19 Solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19
WDR62 WD repeat domain 62
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CASC5 Cancer susceptibility candidate 5
NBN Nibrin
EFTUD2 Elongation factor Tu GTP binding domain containing 2
IER3IP1 Immediate early response 3 interacting protein 1
STIL SCL/TAL1 interrupting locus
CEP135 Centrosomal protein 135 kDa
ZNF335 Zinc finger protein 335
NDE1 nudE nuclear distribution E homolog 1
DIAPH1 Diaphanous homolog 1
KIF11 Kinesin family member 11
Congenital nervous system disorders MCPH1 Microcephalin 1
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
TGIF1 TGFB-induced factor homeobox 1
GRIN2B Glutamate receptor, ionotropic, N-methyl d-aspartate 2B
SLC12A5 Solute carrier family 12 (potassium/chloride transporter), member 5
FLNA Filamin A, alpha
SIX3 SIX homeobox 3
SHH Sonic hedgehog
CDK5RAP2 CDK5 regulatory subunit associated protein 2
NDE1 nudE nuclear distribution E homolog 1
WDR62 WD repeat domain 62
ASPM Asp (abnormal spindle) homolog, microcephaly associated
CENPJ Centromere protein J
STIL SCL/TAL1 interrupting locus
FKTN Fukutin
POMGNT1 Protein O−linked mannose beta1,2−N−acetylglucosaminyltransferase
CEP152 Centrosomal protein 152 kDa
POMT2 Protein−O−mannosyltransferase 2
GLI2 GLI family zinc finger 2
ZNF335 Zinc finger protein 335
Epilepsy syndrome CDKL5 Cyclin−dependent kinase−like 5
CSTB Cystatin B (stefin B)
TSC1 Tuberous sclerosis 1
CACNB4 Calcium channel, voltage−dependent, beta 4 subunit
CLCN2 Chloride channel, voltage−sensitive 2
PCDH19 Protocadherin 19
KCNQ2 Potassium voltage−gated channel, KQT−like subfamily, member 2
CLN5 Ceroid−lipofuscinosis, neuronal 5
ATP1A2 ATPase, Na +/K + transporting, alpha 2 polypeptide
LGI1 Leucine−rich, glioma inactivated 1
SCN1B Sodium channel, voltage−gated, type I, beta subunit
ALDH5A1 Aldehyde dehydrogenase 5 family, member A1
EFHC1 EF−hand domain (C−terminal) containing 1
Encephalitis DDX58 DEAD (Asp−Glu−Ala−Asp) box polypeptide 58
RPSA Ribosomal protein SA
TREX1 Three prime repair exonuclease 1
Demyelinating disease PLP1 Proteolipid protein 1
RTN4 Reticulon 4
GALC Galactosylceramidase
GBS FAS Fas (TNF receptor superfamily, member 6)