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Table 3 Neurological clinical phenotypes associated with ZIKV DEGs

From: Bioinformatic analysis reveals the expression of unique transcriptomic signatures in Zika virus infected human neural stem cells

Disease

Gene symbol

Gene name

Microcephaly

DYRK1A

Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

MCPH1

Microcephalin 1

CASK

Calcium/calmodulin-dependent serine protein kinase (MAGUK family)

PHGDH

Phosphoglycerate dehydrogenase

ARFGEF2

ADP-ribosylation factor guanine nucleotide-exchange factor 2

ASPM

Asp (abnormal spindle) homolog, microcephaly associated

CENPJ

Centromere protein J

CEP152

Centrosomal protein 152 kDa

SLC25A19

Solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19

WDR62

WD repeat domain 62

CDK5RAP2

CDK5 regulatory subunit associated protein 2

CASC5

Cancer susceptibility candidate 5

NBN

Nibrin

EFTUD2

Elongation factor Tu GTP binding domain containing 2

IER3IP1

Immediate early response 3 interacting protein 1

STIL

SCL/TAL1 interrupting locus

CEP135

Centrosomal protein 135 kDa

ZNF335

Zinc finger protein 335

NDE1

nudE nuclear distribution E homolog 1

DIAPH1

Diaphanous homolog 1

KIF11

Kinesin family member 11

Congenital nervous system disorders

MCPH1

Microcephalin 1

ARFGEF2

ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)

TGIF1

TGFB-induced factor homeobox 1

GRIN2B

Glutamate receptor, ionotropic, N-methyl d-aspartate 2B

SLC12A5

Solute carrier family 12 (potassium/chloride transporter), member 5

FLNA

Filamin A, alpha

SIX3

SIX homeobox 3

SHH

Sonic hedgehog

CDK5RAP2

CDK5 regulatory subunit associated protein 2

NDE1

nudE nuclear distribution E homolog 1

WDR62

WD repeat domain 62

ASPM

Asp (abnormal spindle) homolog, microcephaly associated

CENPJ

Centromere protein J

STIL

SCL/TAL1 interrupting locus

FKTN

Fukutin

POMGNT1

Protein O−linked mannose beta1,2−N−acetylglucosaminyltransferase

CEP152

Centrosomal protein 152 kDa

POMT2

Protein−O−mannosyltransferase 2

GLI2

GLI family zinc finger 2

ZNF335

Zinc finger protein 335

Epilepsy syndrome

CDKL5

Cyclin−dependent kinase−like 5

CSTB

Cystatin B (stefin B)

TSC1

Tuberous sclerosis 1

CACNB4

Calcium channel, voltage−dependent, beta 4 subunit

CLCN2

Chloride channel, voltage−sensitive 2

PCDH19

Protocadherin 19

KCNQ2

Potassium voltage−gated channel, KQT−like subfamily, member 2

CLN5

Ceroid−lipofuscinosis, neuronal 5

ATP1A2

ATPase, Na +/K + transporting, alpha 2 polypeptide

LGI1

Leucine−rich, glioma inactivated 1

SCN1B

Sodium channel, voltage−gated, type I, beta subunit

ALDH5A1

Aldehyde dehydrogenase 5 family, member A1

EFHC1

EF−hand domain (C−terminal) containing 1

Encephalitis

DDX58

DEAD (Asp−Glu−Ala−Asp) box polypeptide 58

RPSA

Ribosomal protein SA

TREX1

Three prime repair exonuclease 1

Demyelinating disease

PLP1

Proteolipid protein 1

RTN4

Reticulon 4

GALC

Galactosylceramidase

GBS

FAS

Fas (TNF receptor superfamily, member 6)