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Fig. 6 | Cell & Bioscience

Fig. 6

From: Bioinformatic analysis reveals the expression of unique transcriptomic signatures in Zika virus infected human neural stem cells

Fig. 6

Activation of NF-κB and STATs signaling pathway in ZIKV-infected hNPCs. Cytokines (IL-1 and TNF-α), PAMPs, CD40 and CXCL12 interact with their receptors resulting in activation of the NF-κB pathway. IFN-γ, IL-6 and IL-12 binding to their receptors induces STAT dimerization and translocation to the nucleus. Activation of both the canonical NF-κB and STAT signaling pathways, results in the production of numerous inflammatory cytokines.

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