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Fig. 3 | Cell & Bioscience

Fig. 3

From: Disruption of the Golgi protein Otg1 gene causes defective hormone secretion and aberrant glucose homeostasis in mice

Fig. 3

Impaired glucose homeostasis in Otg1 mutant mice. a Blood glucose levels of newborn Otg1 PB/PB (P1: n = 13; P2: n = 10), Otg1 PB/+ (P1: n = 30; P2: n = 30) and wild-type (P1: n = 16; P2: n = 11) littermates. b Blood glucose levels of free fed or 2-hour starved Otg1 PB/PB (n = 10), Otg1 PB/+ (n = 19) and wild-type (n = 10) littermates at P11. c Intraperitoneal glucose tolerance test (IPGTT) performance of Otg1 PB/PB (n = 4), Otg1 PB/+ (n = 6) and wild-type (n = 3) littermates at P11. d Serum insulin levels of Otg1 PB/PB (n = 10), Otg1 PB/+ (n = 19) and wild-type (n = 10) littermates at P11. e Insulin tolerance test (ITT) results of Otg1 PB/PB (n = 4), Otg1 PB/+ (n = 8) and wild-type (n = 5) littermates at P11. f Serum leptin levels of Otg1 PB/PB (n = 7), Otg1 PB/+ (n = 5) and wild-type (n = 4) littermates. g Serum growth hormone levels of Otg1 PB/PB (n = 17) and wild-type (n = 15) littermates. h Relative IGF-1 expression in Otg1 PB/PB (P1: n = 5; P2: n = 4) and wild-type (P1: n = 3; P11: n = 5) littermates. *p < 0.05, **p < 0.01, ***p < 0.005

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