Fig. 1

A PB insertion effectively abolished Otg1 expression. a Schematic representation of the genomic sequence flanking PB insertion site in Otg1. White box: exon. b Western blot did not detect OTG1 expression in either E13.5 Otg1 ^PB/PB embryos or tissues of P1 Otg1 ^PB/PB mice. c Immunofluorescence staining showed co-localization of OTG1 protein and Giantin in both pancreatic tissues of MEFs from wild-type mice