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Fig. 2 | Cell & Bioscience

Fig. 2

From: Hedgehog pathway is involved in nitidine chloride induced inhibition of epithelial-mesenchymal transition and cancer stem cells-like properties in breast cancer cells

Fig. 2

NC attenuates the migratory capacity and EMT of breast cancer cells. a, b MDA-MB-468 and MCF-7 cells were treated with the indicated concentrations of NC for 48 h. NC significantly inhibited the migration of cells into the denuded areas. The MDA-MB-468 and MCF-7 cells were treated with increasing concentrations of NC (0, 1.0 μM) for 48 h. c, d Photos of the invasive and migration were taken under a microscope with a 200× objective. e, f Both cell types were treated with 0, 1, or 2.5 μM NC for 48 h and then Protein and mRNA expression levels of EMT-related genes were detected. *P < 0.05 or **P < 0.05 compared with the control group

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