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Table 1 Breakpoints detected within the AF9 gene in H2O2-treated cells

From: Potential role of oxidative stress-induced apoptosis in mediating chromosomal rearrangements in nasopharyngeal carcinoma

Cell line treated with H2O2 Breakpoint Remarks
HK1 245,590 This chromosomal break falls within the AF9 region (at coordinates 245252–245612) that translocates with the MLL gene, resulted in MLL-AF9 fusion gene previously identified in ALL patient [GenBank:AM050804]. This breakpoint is three nucleotides different from a breakpoint (at coordinate 245593) reported in cultured normal blood cells treated with VP16 [35]
245,677  
245,823  
245,850  
245,892  
246,110 This breakpoint is four nucleotides different from a breakpoint (at coordinate 246114) reported in CEM cells treated with VP16 [35]
NP69 245,580 This chromosomal break falls within the AF9 region (at coordinates 245252-245612) that translocates with the MLL gene, resulted in MLL-AF9 fusion gene previously identified in ALL patient [GenBank:AM050804]
245,591 This chromosomal break falls within the AF9 region (at coordinates 245252-245612) that translocates with the MLL gene, resulted in MLL-AF9 fusion gene previously identified in ALL patient [GenBank:AM050804]. This breakpoint is two nucleotides different from a breakpoint (at coordinate 245593) reported in cultured normal blood cells treated with VP16 [35]
245,613 This breakpoint is 1 nucleotide different from a breakpoint (at coordinate 245612) identified in ALL patient [GenBank:AM050804]
245,659  
245,703  
245,796  
245,944  
246,000  
246,057  
246,113 This breakpoint is one nucleotide different from a breakpoint (at coordinate 246114) reported in CEM cells treated with VP16 [35]
  1. The nucleotide positions of the chromosomal breaks detected within the AF9 gene were mapped according to the AF9 sequence accessed from Ensembl database [EMBL:ENSG00000171843]