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TableĀ 2 Potential methods for HCC ctDNA detection

From: Circulating tumor DNA in hepatocellular carcinoma: trends and challenges

Technique Detection capability (mutant DNA/total DNA) (%)
Sanger sequencing >10
Pyrosequencing 10
Next-generation sequencing >1
Real-time 1
ARMS 0.1
Digital droplet PCR, BEAMing, PAP, TAM-seq, Safe-SeqS, CAPP-seq, PARE <0.01