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Fig. 6 | Cell & Bioscience

Fig. 6

From: Tyrosine 625 plays a key role and cooperates with tyrosine 630 in MPL W515L-induced signaling and myeloproliferative neoplasms

Fig. 6

The effect of tyrosine 625 and 630 on hematopoiesis altered by MPL W515L in the bone marrow of recipient mice. a Analysis of hematopoietic stem cells (HSC) and progenitor cells (HPC) in the bone marrow cells from mice (n = 3) receiving bone marrow cells transduced with different MPL constructs as indicated. b Bone marrow cells were also used for analysis of CMP, GMP and MEP. c The myeloid, megakaryocyte, or erythrocyte lineages in the bone marrow from recipient mice were also analyzed. Asterisk indicates significance (p < 0.05) compared to MPL W515L

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