From: Regulation of mitochondrial functions by protein phosphorylation and dephosphorylation
Proteins | Evidences of mitochondria localization | Functions in mitochondria | References |
---|---|---|---|
Abl | Co-IP, WB, IF | Apoptosis | |
Src | WB, IP, Co-IP, Kinase array | Cytochrome C oxidase, ROS production and respiration | |
EGFR | WB, IP, IF | Apoptosis, respiration and cellular metabolism | |
Akt | WB, IP, Co-IP, IF | Cell survival and regulation of respiration | |
JNK | WB, IF | Apoptosis, neuro inflammation and mitochondria biogenesis Possibly regulation of signal transduction | |
ERK1/2 | WB, IF | Respiration, ATP production, membrane potential, mitophagy, autophagic cell death, MPTP and steroidogenesis | |
P38 MAPK | WB, IF, GST | Apoptosis | |
GSK3β | WB, Co-IP | MPTP and energy metabolism | |
PKA | WB, IF, DEAE, GST, in vitro kinase assay | Respiration, mitochondria division and steroidogenesis | |
PKC | WB, IP, IF | Respiration, KÂ +Â channel and apoptosis | |
PINK1 | WB, IF | Mitochondria trafficking at outer membrane. Pathogenesis of PD. Localized translation of respiration chain complex | |
MKP1 | WB, IF | Apoptosis | [142] |
Shp2 | WB, Co-IP | ROS production | |
PTPs | WB, Co-IP, IF | ATP production | |
PTEN | WB, IF | Apoptosis and ATP production |