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Table 1 Mitochondrial kinases/phosphatases

From: Regulation of mitochondrial functions by protein phosphorylation and dephosphorylation

Proteins

Evidences of mitochondria localization

Functions in mitochondria

References

Abl

Co-IP, WB, IF

Apoptosis

[3, 4]

Src

WB, IP, Co-IP, Kinase array

Cytochrome C oxidase, ROS production and respiration

[10, 11, 15–18]

EGFR

WB, IP, IF

Apoptosis, respiration and cellular metabolism

[33–40]

Akt

WB, IP, Co-IP, IF

Cell survival and regulation of respiration

[43–45, 47–49]

JNK

WB, IF

Apoptosis, neuro inflammation and mitochondria biogenesis

Possibly regulation of signal transduction

[50–57, 60]

ERK1/2

WB, IF

Respiration, ATP production, membrane potential, mitophagy, autophagic cell death, MPTP and steroidogenesis

[51, 53, 61–66]

P38 MAPK

WB, IF, GST

Apoptosis

[51, 67, 68]

GSK3β

WB, Co-IP

MPTP and energy metabolism

[70–72, 74, 75]

PKA

WB, IF, DEAE, GST, in vitro kinase assay

Respiration, mitochondria division and steroidogenesis

[87, 89– 93, 95, 98, 99, 102]

PKC

WB, IP, IF

Respiration, K + channel and apoptosis

[105–109]

PINK1

WB, IF

Mitochondria trafficking at outer membrane. Pathogenesis of PD. Localized translation of respiration chain complex

[121, 122, 125–128, 130, 131]

MKP1

WB, IF

Apoptosis

[142]

Shp2

WB, Co-IP

ROS production

[16, 151, 152]

PTPs

WB, Co-IP, IF

ATP production

[12, 13, 161, 162]

PTEN

WB, IF

Apoptosis and ATP production

[164, 165]

  1. WB western blot, Co-IP Co-immunoprecipitation, IP Immunoprecipitation, IF Immunofluorescence, GST GST pull-down assay, DEAE diethylaminoethyl cellulose chromatography