Skip to main content


Fig. 6 | Cell & Bioscience

Fig. 6

From: Buccal injection of synthetic HPV long peptide vaccine induces local and systemic antigen-specific CD8+ T-cell immune responses and antitumor effects without adjuvant

Fig. 6

Effect of TLR4 Knockout on the antitumor response of synthetic HPV-16 E7aa 43-62 long peptide vaccine. 3 × 104 TC-1-Luc cells were submucosally injected into the right buccal area of C57BL/6 or C57BL/10ScNJ (TLR4−/−) mice (five per group). Three days after tumor injection, mice were vaccinated intratumorally with or without 50 μg of synthetic HPV-16 E7aa 43-62 peptide for four times in a 4-day intervals. Figure represents the Kaplan–Meier survival analysis of mice in TLR4 knockout experiment

Back to article page