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Fig. 5 | Cell & Bioscience

Fig. 5

From: Buccal injection of synthetic HPV long peptide vaccine induces local and systemic antigen-specific CD8+ T-cell immune responses and antitumor effects without adjuvant

Fig. 5

Comparison of antitumor effects induced by synthetic HPV-16 E7aa 43-62 long peptide vaccine in various tumor model. C57BL/6 mice (five per group) received either 3 × 104 TC-1-Luc cells injection submucosally into the right buccal area or 1 × 105 TC-1-Luc cells injection subcutaneously into the abdomen. Three days after tumor injection, mice were vaccinated intratumorally with or without 50 μg of synthetic HPV-16 E7aa 43-62 peptide for four times in a 4-day intervals. a Line graph depicting the change in mean luminescence intensity of tumor bearing mice after buccal tumor injection (mean ± SD). b Line graph depicting the change in mean luminescence intensity of tumor bearing mice after subcutaneous tumor injection (mean ± SD)

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