Fig. 1

Characterization of antitumor effect in tumor bearing mice treated with intratumoral synthetic HPV-16 E7aa 43-62 long peptide vaccination in buccal mucosal region. 3 × 10⁴ TC-1-Luc cells were submucosally injected into the right buccal area of C57BL/6 mice (five per group). Three days after tumor injection, mice were vaccinated intratumorally with or without 50 μg of synthetic HPV-16 E7aa 43-62 peptide for four times in a 4-day intervals. a Schematic diagram of treatment regimens. b Line graph depicting the change in mean luminescence intensity of tumor bearing mice after tumor injection (mean ± SD). c Kaplan–Meier survival analysis of mice