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Table 2 Coactivator complexes functions at the particular stages of the transcription activation cycle

From: On the way of revealing coactivator complexes cross-talk during transcriptional activation

Family Stage of action Real or predicted effect during transcription activation stage References
Promoter structure maintenance
 Mediator Nucleosome removal Stimulation of chromatin remodelers recruitment [7, 49]
GTFs recruitment Stabilization of GTFs on promoter [43]
Pol II recruitment Making GTFs competent for Pol II recruitment [44]
Chromatin remodeling complexes
 SWI/SNF Activator recruitment Stimulation of activator binding [15, 62, 63]
Nucleosome removal Promoter clearance from the nucleosomes [9, 59, 60]
GTFs recruitment TFIID binding [64, 65]
RNA synthesis initiation Pol II pausing [66]
Productive elongation Modulation of transcription elongation and splicing [15, 6668]
 ISWI Activator recruitment Promoter clearance from the nucleosomes [9, 70]
 CHD Nucleosome removal Stabilization of the open chromatin structure on promoter [7678]
Productive elongation Modulation of transcription elongation and splicing [80, 82, 85]
 Ino80 Nucleosome removal Promoter clearance from the nucleosomes [91, 92, 94, 95]
Histone-modifying complexes
 Methyltransferases
  Set1/MLL Repressor removal Trimethylation of Histone H3 on K4 [9]
Productive elongation [22, 32]
  CARM1 Nucleosome removal Mono and dimethylation of Histone H3 on R17 [15, 16]
  PRMT1 Nucleosome removal Mono and dimethylation of Histone H4 on R3 [15, 16]
  Set2 Productive elongation Trimethylation of Histone H3 on K36 [31, 32]
 Demethylase
  KDM5/Lid RNA synthesis initiation Removal of H3K4me3 modification [39]
 Acetyltransferases
  SAGA Activator recruitment Acetylation of Histone H3 on K14 [15, 20, 29]
  GTFs recruitment Acetylation of Histone H3 on K9 and Histone H4 [20, 29, 30]
  CBP/p300 GTFs recruitment Acetylation of Histone H4 at multiple sites [15]
 Ubiquitin ligase
  Bre Productive elongation Ubiquitination of H2B at K120 [3436]
 Deubiquitinase
  DUB module in SAGA Repressor removal Deubiquitination of H2B at K120 [9]
Productive elongation [38]