On the way of revealing coactivator complexes cross-talk during transcriptional activation

Krasnov, Aleksey N.; Mazina, Marina Yu.; Nikolenko, Julia V.; Vorobyeva, Nadezhda E.

doi:10.1186/s13578-016-0081-y

Cell & Bioscience

Table 2 Coactivator complexes functions at the particular stages of the transcription activation cycle

From: On the way of revealing coactivator complexes cross-talk during transcriptional activation

Family	Stage of action	Real or predicted effect during transcription activation stage	References
Promoter structure maintenance
Mediator	Nucleosome removal	Stimulation of chromatin remodelers recruitment	[7, 49]
	GTFs recruitment	Stabilization of GTFs on promoter	[43]
	Pol II recruitment	Making GTFs competent for Pol II recruitment	[44]
Chromatin remodeling complexes
SWI/SNF	Activator recruitment	Stimulation of activator binding	[15, 62, 63]
	Nucleosome removal	Promoter clearance from the nucleosomes	[9, 59, 60]
	GTFs recruitment	TFIID binding	[64, 65]
	RNA synthesis initiation	Pol II pausing	[66]
	Productive elongation	Modulation of transcription elongation and splicing	[15, 66–68]
ISWI	Activator recruitment	Promoter clearance from the nucleosomes	[9, 70]
CHD	Nucleosome removal	Stabilization of the open chromatin structure on promoter	[76–78]
CHD	Productive elongation	Modulation of transcription elongation and splicing	[80, 82, 85]
Ino80	Nucleosome removal	Promoter clearance from the nucleosomes	[91, 92, 94, 95]
Histone-modifying complexes
Methyltransferases
Set1/MLL	Repressor removal	Trimethylation of Histone H3 on K4	[9]
Set1/MLL	Productive elongation	Trimethylation of Histone H3 on K4	[22, 32]
CARM1	Nucleosome removal	Mono and dimethylation of Histone H3 on R17	[15, 16]
PRMT1	Nucleosome removal	Mono and dimethylation of Histone H4 on R3	[15, 16]
Set2	Productive elongation	Trimethylation of Histone H3 on K36	[31, 32]
Demethylase
KDM5/Lid	RNA synthesis initiation	Removal of H3K4me3 modification	[39]
Acetyltransferases
SAGA	Activator recruitment	Acetylation of Histone H3 on K14	[15, 20, 29]
	GTFs recruitment	Acetylation of Histone H3 on K9 and Histone H4	[20, 29, 30]
CBP/p300	GTFs recruitment	Acetylation of Histone H4 at multiple sites	[15]
Ubiquitin ligase
Bre	Productive elongation	Ubiquitination of H2B at K120	[34–36]
Deubiquitinase
DUB module in SAGA	Repressor removal	Deubiquitination of H2B at K120	[9]
DUB module in SAGA	Productive elongation	Deubiquitination of H2B at K120	[38]

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ISSN: 2045-3701

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