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Table 1 Direct PRH target genes associated with cancer

From: Misregulation of the proline rich homeodomain (PRH/HHEX) protein in cancer cells and its consequences for tumour growth and invasion

Target gene Function and pathways Regulation Evidence References
ENG (Endoglin/CD105) TGFβ co-receptor: neoangiogenesis, cell invasion, metastasis, cell proliferation Activated ChIP, EMSA [49]
ESM1 (ESM-1/Endocan) Cell–cell contacts: neoangiogenesis, metastasis, cell proliferation Repressed ChIP, EMSA [43]
GSC (Goosecoid) Transcription factor: epithelial-mesechymal transition Repressed ChIP, EMSA [10, 24]
KDR (FLK1/VEGFR2) VEGF receptor: neoangiogenesis, cell invasion, metastasis, cell proliferation Repressed ChIP, EMSA [44]
VEGFA (VEGF/VPF) Growth factor: neoangiogenesis, cell invasion, metastasis, cell proliferation Repressed ChIP, EMSA [44]
FLT1 (VEGFR1) VEGF receptor: neoangiogenesis, cell invasion, metastasis, cell proliferation Repressed ChIP, EMSA [44]