Skip to main content

Table 1 Direct PRH target genes associated with cancer

From: Misregulation of the proline rich homeodomain (PRH/HHEX) protein in cancer cells and its consequences for tumour growth and invasion

Target gene

Function and pathways

Regulation

Evidence

References

ENG (Endoglin/CD105)

TGFβ co-receptor: neoangiogenesis, cell invasion, metastasis, cell proliferation

Activated

ChIP, EMSA

[49]

ESM1 (ESM-1/Endocan)

Cell–cell contacts: neoangiogenesis, metastasis, cell proliferation

Repressed

ChIP, EMSA

[43]

GSC (Goosecoid)

Transcription factor: epithelial-mesechymal transition

Repressed

ChIP, EMSA

[10, 24]

KDR (FLK1/VEGFR2)

VEGF receptor: neoangiogenesis, cell invasion, metastasis, cell proliferation

Repressed

ChIP, EMSA

[44]

VEGFA (VEGF/VPF)

Growth factor: neoangiogenesis, cell invasion, metastasis, cell proliferation

Repressed

ChIP, EMSA

[44]

FLT1 (VEGFR1)

VEGF receptor: neoangiogenesis, cell invasion, metastasis, cell proliferation

Repressed

ChIP, EMSA

[44]