Target gene | Function and pathways | Regulation | Evidence | References |
---|---|---|---|---|
ENG (Endoglin/CD105) | TGFβ co-receptor: neoangiogenesis, cell invasion, metastasis, cell proliferation | Activated | ChIP, EMSA | [49] |
ESM1 (ESM-1/Endocan) | Cell–cell contacts: neoangiogenesis, metastasis, cell proliferation | Repressed | ChIP, EMSA | [43] |
GSC (Goosecoid) | Transcription factor: epithelial-mesechymal transition | Repressed | ChIP, EMSA | |
KDR (FLK1/VEGFR2) | VEGF receptor: neoangiogenesis, cell invasion, metastasis, cell proliferation | Repressed | ChIP, EMSA | [44] |
VEGFA (VEGF/VPF) | Growth factor: neoangiogenesis, cell invasion, metastasis, cell proliferation | Repressed | ChIP, EMSA | [44] |
FLT1 (VEGFR1) | VEGF receptor: neoangiogenesis, cell invasion, metastasis, cell proliferation | Repressed | ChIP, EMSA | [44] |