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Fig. 4 | Cell & Bioscience

Fig. 4

From: Molecular and cytological analyses reveal distinct transformations of intestinal epithelial cells during Xenopus metamorphosis

Fig. 4

Clusters of proliferating adult intestinal epithelial cells at the climax of natural metamorphosis lack IFABP. Tadpoles at premetamorphic stage 54 (A), climax (B stage 62), and end of metamorphosis (C, stage 66) were injected with EdU 1 h before being sacrificed. Cross-sections of the intestine from the resulting tadpoles were double-stained for EdU and IFABP by immunohistochemistry. Higher magnifications of boxed areas in (AC) are shown in (a′–c′) and (a″–c″). The dotted lines depict the epithelium-mesenchyme boundary (see Fig. 1). Note that the EdU-labeled proliferating cells in the epithelium were few and expressed IFABP at premetamorphosis (A) and increased in form of clustered cells that lacked IFABP at the climax of metamorphosis (B, b″). At the end of metamorphosis, EdU-labeled proliferating cells were localized mainly in the troughs of the epithelial folds where IFABP expression was low (C, c″)

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