Fig. 4

Involvement of P38 and JNK in rDP2-mediated upregulation of Fas and FasL in BEAS-2B cell. Cells were pretreated with or without indicated inhibitors, and then treated with rDP2 at indicated concentrations for 24 h (a) or 6 h (b, c). The treated cells were subjected to a immunoblotting, b RT-PCR, or c qPCR for Fas and FasL expression, respectively. Signals of tubulin and GAPDH were used as internal control for immunoblotting and RT-PCR, respectively. Three independent experiments were performed for statistical analysis. #p < 0.05 as compared to GST treatment. *p < 0.05 and **p < 0.01 as compared to 40 μg/mL rDP2 treatment