Fig. 9

Schema depicting the proposed mechanisms for MTMR14 deletion-induced obesity and complications. On one hand, MTMR14 deletion dysregulates a number of genes then releases a series of inflammatory cytokines and adipokines. On the other hand, MTMR14 deletion alters PI3K/AKT and ERK signaling pathway. As a result, MTMR14 deletion induces obesity and complications