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Fig. 2 | Cell & Bioscience

Fig. 2

From: NF-κB in inflammation and renal diseases

Fig. 2

Canonical and noncanonical NF-κB signaling pathways. The canonical NF-κB pathway responds to signals from diverse receptors, including pattern-recognition receptors (PRRs) present on cell surface or intracellular environment, TNF receptors (TNFRs), other cytokine receptors, as well as T cell receptor (TCR) and B cell receptor (BCR). The noncanonical NF-κB pathway is activated by a selective subset of TNFR superfamily members. Canonical NF-κB signaling involves activation of the trimeric IKK complex by the MAP3 K TAK1, IKK-mediated IκBα phosphorylation and subsequent degradation, and nuclear translocation of the prototypical NF-κB heterodimer RelA/p50. Noncanonical NF-κB signaling relies on NF-κB inducing kinase (NIK), which together with IKKα mediate phosphorylation and processing of p100, causing generation of p52 and nuclear translocation of p52/RelB complex. Compared with the pleotropic roles of canonical pathway, noncanonical NF-κB has more specific functions. PRR pattern-recognition receptors, TNFR TNF receptor, TCR T cell receptor, BCR B cell receptor, NIK NF-κB inducing kinase

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