Ouabain prevents pathological cardiac hypertrophy and heart failure through activation of phosphoinositide 3-kinase α in mouse

Table 2 Comparison of cardiac hemodynamic function (baseline) of Con and p85-KO mouse hearts

	BW (g)	HR (bpm)	Ves (LII)	Ved (LII)	Pes (mmHg)	Ped (mmHg)	SV (Lll)	EF (%)	dP/dt (mmHg/s)	−dP/dt (−mm Hg/s)
Con	23.1 ± 3.0	339 ± 32	14.8 ± 2.3	22.2 ± 1.2	79.2 ± 5.6	7.0 ± 2.7	10.2 ± 1.7	48.3 ± 8.4	4452 ± 924	3998 ± 858
KO	21.3 ± 1.8	271 ± 11	12.5 ± 2.0	17.8 ± 2.4	75.3 ± 1.8	6.5 ± 1.4	7.9 ± 1.1	44.4 ± 5.9	3732 ± 385	3092 ± 444

Hemodynamic function of p85-KO and the Cre controls (12 week-old, male) were measured by cardiac catheter as described in “Method”. There is no statistical significance between the Con and KO mice
BW body weight; HR heart rate; Ves end systolic volume; Ved end diastolic volume; Pes end systolic pressure; Ped end diastolic pressure; SV stroke volume; EF ejection fraction; +dP/dt the rate of pressure development; −dP/dt the rate of relaxation. Con n=4; KO n=7

ISSN: 2045-3701