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Table 2 Comparison of cardiac hemodynamic function (baseline) of Con and p85-KO mouse hearts

From: Ouabain prevents pathological cardiac hypertrophy and heart failure through activation of phosphoinositide 3-kinase α in mouse

  BW (g) HR (bpm) Ves (LII) Ved (LII) Pes (mmHg) Ped (mmHg) SV (Lll) EF (%) dP/dt (mmHg/s) −dP/dt (−mm Hg/s)
Con 23.1 ± 3.0 339 ± 32 14.8 ± 2.3 22.2 ± 1.2 79.2 ± 5.6 7.0 ± 2.7 10.2 ± 1.7 48.3 ± 8.4 4452 ± 924 3998 ± 858
KO 21.3 ± 1.8 271 ± 11 12.5 ± 2.0 17.8 ± 2.4 75.3 ± 1.8 6.5 ± 1.4 7.9 ± 1.1 44.4 ± 5.9 3732 ± 385 3092 ± 444
  1. Hemodynamic function of p85-KO and the Cre controls (12 week-old, male) were measured by cardiac catheter as described in “Method”. There is no statistical significance between the Con and KO mice
  2. BW body weight; HR heart rate; Ves end systolic volume; Ved end diastolic volume; Pes end systolic pressure; Ped end diastolic pressure; SV stroke volume; EF ejection fraction; +dP/dt the rate of pressure development; −dP/dt the rate of relaxation. Con n=4; KO n=7