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Fig. 6 | Cell & Bioscience

Fig. 6

From: Ouabain prevents pathological cardiac hypertrophy and heart failure through activation of phosphoinositide 3-kinase α in mouse

Fig. 6

Effects of ouabain on TAC-induced cardiac dysfunction in Con and p85-KO mice. Experiments were done as described in “Methods”. Left ventricular cardiac functions were monitored by echocardiography before and after 8 weeks of the TAC or sham surgery. Ouabain was infused subcutaneously (50 μg/kg/day) by ALZET osmotic pumps for continuous dosing for the first 4 weeks. a Fraction shortening, FS % in Con and KO mice. b representative echocardiographic M-mode views of mouse left ventricles at week 8 after surgery. c myocardial performance index (MPI) in Con and KO mice. d representative Pulsed-Wave Doppler flow used for MPI calculation. n = 6 ~ 7, *P < 0.05 vs. Sham; # P < 0.05 vs. TAC

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