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Table 1 PML post-translational modifications, regulators and effects of these modifications on PML protein levels

From: The function, regulation and therapeutic implications of the tumor suppressor protein, PML

Regulators Effect on PML Target region/sites References
KLHL20 (MLN4924), SIAH, E6AP, UHRF1 Down-regulates PML protein abundance by promoting ubiquitination   [120124]
RNF4   SUMO-dependent [118, 119]
KLHL39, USP11 Up-regulates PML protein by blocking ubiquitination   [125, 129]
MageA, HDAC7, PIAS1, SIRT1 Regulates PML SUMOylation K65, K160, K490 [132134]
K490 [116, 131]
p300 Acetylation K487, K515 [146]
SIRT1, SIRT5 De-acetylation, increase K490SUMOylation K487 [9, 116]
Chk2 Phosphorylation S117 [45]
CDK1/2 S518 [122]
ERK2 S403, S505 [142]
CK2 (Emodin) S565a [143]
BMK1 (XMD9-92) S8, S38 [144]
HIPK2 S403, T409 [145]
SCP1, SCP2 and SCP3 De-phosphorylation S518 [128]
Pin1 Isomerization pS518-P519 [122, 141, 142]
  1. PML protein is controlled by several post-translational modifications, including ubquitination, SUMOylation, acetylation, phosphorylation and isomerization
  2. a Annotated as S517 in reference due to different PML isoform