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Fig. 2 | Cell & Bioscience

Fig. 2

From: The function, regulation and therapeutic implications of the tumor suppressor protein, PML

Fig. 2

A schematic diagram of PML functional domains. All PML isoforms share the same N-terminal 418 amino acids, which contain RING (R), B-Box1 (B1), B-Box1 (B2) and coiled coil (CC) domains. Nuclear PML isoforms share the same N-terminal 552 amino acids, which in addition to RBCC, contains a nuclear localization signal (NLS) and a SUMO-interacting motif (SIM) (66) present in PML isoforms I–V. Only PMLI contains a putative nuclear export signal (NES) at its C-terminus

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