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Table 1 Comparison of differentially expressed genes with published CRC microarray studies

From: Integrated transcriptional profiling and genomic analyses reveal RPN2 and HMGB1 as promising biomarkers in colorectal cancer

Gene symbol Fold changea Tumors with prognosis gene signaturesb Tumors from other microarraysc
TIMP1 8.34 232 52
AARSd 4.48   30
PEA15d 4.23 215 22
CD59 1.61 232  
IFITM1 3.03   106
HMGB1d 2.07 215 496
RPN2d 1.91   15
IGF2R 1.75 215 107
IGFBP3d 2.29 232 706
NPM1 2.60 87 679
NQO1d 3.77 55 200
TGFB1 2.35   531
AKT1 3.33   43
HYOU1d 2.16   30
STAT1d 2.83 215 30
  1. aThe fold changes of differential gene expression between Stage II CRC tumor and normal tissues were extracted from the microarray data presented in Fig. 1
  2. bPrognosis gene signatures were extracted from the publication of Sanz-Pamplona et al., which surveyed 29 microarray studies with patient’s data of recurrence, metastasis and survival [25]
  3. cAdditional microarray data from 50 previous publications was extracted from CRC tumor and metastatic specimens (Additional file 1: Table S3). The indicated number stands for tumor specimens with increased gene expression
  4. dRefers to genes that are involved in transcriptional regulation (Fig. 3; Additional file 1: Table S1) and an overlapping with TCGA data (Additional file 2: Figure S2)