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Table 1 Comparison of differentially expressed genes with published CRC microarray studies

From: Integrated transcriptional profiling and genomic analyses reveal RPN2 and HMGB1 as promising biomarkers in colorectal cancer

Gene symbol

Fold changea

Tumors with prognosis gene signaturesb

Tumors from other microarraysc

TIMP1

8.34

232

52

AARSd

4.48

 

30

PEA15d

4.23

215

22

CD59

1.61

232

 

IFITM1

3.03

 

106

HMGB1d

2.07

215

496

RPN2d

1.91

 

15

IGF2R

1.75

215

107

IGFBP3d

2.29

232

706

NPM1

2.60

87

679

NQO1d

3.77

55

200

TGFB1

2.35

 

531

AKT1

3.33

 

43

HYOU1d

2.16

 

30

STAT1d

2.83

215

30

  1. aThe fold changes of differential gene expression between Stage II CRC tumor and normal tissues were extracted from the microarray data presented in Fig. 1
  2. bPrognosis gene signatures were extracted from the publication of Sanz-Pamplona et al., which surveyed 29 microarray studies with patient’s data of recurrence, metastasis and survival [25]
  3. cAdditional microarray data from 50 previous publications was extracted from CRC tumor and metastatic specimens (Additional file 1: Table S3). The indicated number stands for tumor specimens with increased gene expression
  4. dRefers to genes that are involved in transcriptional regulation (Fig. 3; Additional file 1: Table S1) and an overlapping with TCGA data (Additional file 2: Figure S2)