Fig. 3

Evaluation of genomic alterations in TCGA CRC dataset. a Genomic alterations, including copy number variations (CNVs), mutations and gene expression of each gene candidate were extracted from the TCGA colorectal cancer (CRC) database. The X- and Y-axis represent genomic alterations and case number, respectively. b Variations of mRNA expression versus CNVs and chromosomal locations for individual gene candidates are shown. CNV categories include homozygous deletions (Homodel), heterozygous deletions (Hetloss), diploid, gain and amplification (Amp). mRNA was expressed as 25th, 50th, and 75th percentile and whiskers represent minimal and maximal values, excluding the outliers. Red circle indicates missense mutations