Fig. 2

Overgrowth of testes and fertility loss in Pten ^−/− mice. a Curve of organ coefficient of Pten ^+/+ and Pten ^−/− testes with age. Horizontal bars indicate mean values, n = 3, * P < 0.05. b In vivo fertility assay of Pten ^+/+ and Pten ^−/− mice. The mating test was divided into three groups according to the male’s age: 35–60 days old, 61–100 days old, and over 100 days old. Horizontal bars indicate mean values, n = 22 ** P < 0.01.