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Fig. 4 | Cell & Bioscience

Fig. 4

From: Co-administration with DNA encoding papillomavirus capsid proteins enhances the antitumor effects generated by therapeutic HPV DNA vaccination

Fig. 4

In vivo tumor treatment experiments in mice vaccinated with CRT/E7 DNA mixed with BPV1 L1 DNA. C57BL/6 mice (five per group) were first challenged with 1x105/mouse of TC-1 tumor cells subcutaneously. One week after tumor challenge, mice were treated intradermally via gene gun with 2 μg/mouse of CRT/E7 DNA alone, BPV1 L1 DNA alone or CRT/E7 DNA in combination with BPV1 L1 DNA. Vaccinated mice were boosted twice at 1-week intervals with the same dose and regimen. Mice were sacrificed on day 30 after the last vaccination. Tumor growth were monitored twice weekly by caliper measurements and palpations. a Line graph depicting the tumor volume over time of tumor-bearing mice treated with CRT/E7 DNA and/or BPV1 L1 DNA. b Kaplan-Meier survival analysis of tumor-bearing mice treated with CRT/E7 DNA and/or BPV1 L1 DNA. The data presented are from one representative experiment of the two performed. * indicates p < 0.05

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