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Fig. 5 | Cell & Bioscience

Fig. 5

From: Peli1 negatively regulates type I interferon induction and antiviral immunity in the CNS

Fig. 5

Peli1 deficiency promotes IFN-I expression and anti-viral defense by microglia in an in vivo model of VSV infection. a-c QPCR analysis of the indicated genes in FACS-sorted microglia, astrocytes, and neuron derived from the WT or Peli1-KO mice 24 h after intracranial infection with VSV-GFP (1 × 107 pfu). d,e Flow cytometric analysis of GFP expression in CD11b+ microglia isolated from the brain of WT or Peli1-KO mice 24 h after intracranial infection with VSV-GFP (1 × 107 pfu). Data are presented as a representative plot (d) and summary graph of the percentage of GFP+ microglia (b). *P < 0.05; **P < 0.01

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