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Fig. 1 | Cell & Bioscience

Fig. 1

From: Apoptotic cell-linked immunoregulation: implications for promoting immune tolerance in transplantation

Fig. 1

A proposed model to induce alloantigen-specific immune tolerance for transplantation. The model can be divided into three steps, i.e. induction of apoptotic cells, creation of an immunoregulatory milieu and generation of alloantigen-specific Treg cells. Once the alloantigen-specific Treg cells are generated, the allograft can be transplanted and should be accepted indefinitely. iDC: immature dendritic cells; IL-10, interleukin-10; Mo, macrophage; T, T cell; TGF-β, transforming-growth factor-β

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