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Table 6 Genes with increased methylation that mapped to the Wnt/β-catenin pathway by IPA

From: Association of aberrant DNA methylation in Apcmin/+ mice with the epithelial-mesenchymal transition and Wnt/β-catenin pathways: genome-wide analysis using MeDIP-seq

Symbol

Gene name

log2 Fold Change

Location

Type(s)

SOX11

SRY (sex determining region Y)-box 11

3.614

Nucleus

transcription regulator

TLE1

transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)

3.462

Nucleus

transcription regulator

SOX2

SRY (sex determining region Y)-box 2

3.292

Nucleus

transcription regulator

WNT5A

wingless-type MMTV integration site family, member 5A

3.292

Extracellular Space

cytokine

WNT10A

wingless-type MMTV integration site family, member 10A

3.100

Extracellular Space

other

CDH5

cadherin 5, type 2 (vascular endothelium)

2.877

Plasma Membrane

other

DKK3

dickkopf WNT signaling pathway inhibitor 3

2.877

Extracellular Space

cytokine

HDAC1

histone deacetylase 1

2.877

Nucleus

transcription regulator

PPP2R3A

protein phosphatase 2, regulatory subunit B”, alpha

2.877

Nucleus

phosphatase

RUVBL2

RuvB-like AAA ATPase 2

2.877

Nucleus

transcription regulator

UBD

ubiquitin D

2.877

Nucleus

other

FZD1

frizzled class receptor 1

2.752

Plasma Membrane

G-protein coupled receptor

CDH12

cadherin 12, type 2 (N-cadherin 2)

2.614

Plasma Membrane

other

FZD8

frizzled class receptor 8

2.614

Plasma Membrane

G-protein coupled receptor

MYC

v-myc avian myelocytomatosis viral oncogene homolog

2.614

Nucleus

transcription regulator

SOX4

SRY (sex determining region Y)-box 4

2.614

Nucleus

transcription regulator

SOX6

SRY (sex determining region Y)-box 6

2.614

Nucleus

transcription regulator

APC2

adenomatosis polyposis coli 2

2.292

Cytoplasm

enzyme

APPL2

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2

2.292

Cytoplasm

other

CSNK2A1

casein kinase 2, alpha 1 polypeptide

2.292

Cytoplasm

kinase

MMP7

matrix metallopeptidase 7 (matrilysin, uterine)

2.292

Extracellular Space

peptidase

NR5A2

nuclear receptor subfamily 5, group A, member 2

2.292

Nucleus

ligand-dependent nuclear receptor

PIN1

peptidylprolyl cis/trans isomerase, NIMA-interacting 1

2.292

Nucleus

enzyme

TGFB2

transforming growth factor, beta 2

2.292

Extracellular Space

growth factor

WNT2

wingless-type MMTV integration site family member 2

2.292

Extracellular Space

cytokine

AKT3

v-akt murine thymoma viral oncogene homolog 3

2.100

Cytoplasm

kinase

FRAT1

frequently rearranged in advanced T-cell lymphomas

2.100

Cytoplasm

other

WNT2B

wingless-type MMTV integration site family, member 2B

2.100

Extracellular Space

other

WNT16

wingless-type MMTV integration site family, member 16

2.029

Extracellular Space

other