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Table 5 Genes with decreased methylation that mapped to the regulation of the EMT pathway by IPA

From: Association of aberrant DNA methylation in Apcmin/+ mice with the epithelial-mesenchymal transition and Wnt/β-catenin pathways: genome-wide analysis using MeDIP-seq

Symbol Gene name log2 Fold Change Location Type(s)
PTPN11 protein tyrosine phosphatase, non-receptor type 11 −3.877 Cytoplasm phosphatase
PDGFD platelet derived growth factor D −3.167 Extracellular Space growth factor
RRAS2 related RAS viral (r-ras) oncogene homolog 2 −3.090 Plasma Membrane enzyme
FGF10 fibroblast growth factor 10 −2.877 Extracellular Space growth factor
FGF12 fibroblast growth factor 12 −2.877 Extracellular Space other
CDH2 cadherin 2, type 1, N-cadherin (neuronal) −2.708 Plasma Membrane other
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 −2.708 Nucleus transcription regulator
mir-155 microRNA 155 −2.708 Cytoplasm microRNA
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 −2.708 Cytoplasm growth factor
PSEN2 presenilin 2 −2.708 Cytoplasm peptidase
TGFB3 transforming growth factor, beta 3 −2.708 Extracellular Space growth factor
SOS1 son of sevenless homolog 1 (Drosophila) −2.515 Cytoplasm other
WNT11 wingless-type MMTV integration site family, member 11 −2.515 Extracellular Space other
SMAD4 SMAD family member 4 −2.292 Nucleus transcription regulator
WNT7A wingless-type MMTV integration site family, member 7A −2.292 Extracellular Space cytokine
SMAD2 SMAD family member 2 −2.167 Nucleus transcription regulator
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) −2.167 Nucleus transcription regulator
CLDN3 claudin 3 −2.029 Plasma Membrane transmembrane receptor
GAB1 GRB2-associated binding protein 1 −2.029 Cytoplasm other
HMGA2 -- −2.029 Other other
RAF1 Raf-1 proto-oncogene, serine/threonine kinase −2.029 Cytoplasm kinase
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) −2.029 Nucleus transcription regulator
TWIST1 twist family bHLH transcription factor 1 −2.029 Nucleus transcription regulator
WNT7B wingless-type MMTV integration site family, member 7B −2.029 Extracellular Space other
WNT8B wingless-type MMTV integration site family, member 8B −2.029 Extracellular Space other