Table 5 Genes with decreased methylation that mapped to the regulation of the EMT pathway by IPA
Symbol | Gene name | log2 Fold Change | Location | Type(s) |
|---|---|---|---|---|
PTPN11 | protein tyrosine phosphatase, non-receptor type 11 | −3.877 | Cytoplasm | phosphatase |
PDGFD | platelet derived growth factor D | −3.167 | Extracellular Space | growth factor |
RRAS2 | related RAS viral (r-ras) oncogene homolog 2 | −3.090 | Plasma Membrane | enzyme |
FGF10 | fibroblast growth factor 10 | −2.877 | Extracellular Space | growth factor |
FGF12 | fibroblast growth factor 12 | −2.877 | Extracellular Space | other |
CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | −2.708 | Plasma Membrane | other |
ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | −2.708 | Nucleus | transcription regulator |
mir-155 | microRNA 155 | −2.708 | Cytoplasm | microRNA |
PIK3C3 | phosphatidylinositol 3-kinase, catalytic subunit type 3 | −2.708 | Cytoplasm | growth factor |
PSEN2 | presenilin 2 | −2.708 | Cytoplasm | peptidase |
TGFB3 | transforming growth factor, beta 3 | −2.708 | Extracellular Space | growth factor |
SOS1 | son of sevenless homolog 1 (Drosophila) | −2.515 | Cytoplasm | other |
WNT11 | wingless-type MMTV integration site family, member 11 | −2.515 | Extracellular Space | other |
SMAD4 | SMAD family member 4 | −2.292 | Nucleus | transcription regulator |
WNT7A | wingless-type MMTV integration site family, member 7A | −2.292 | Extracellular Space | cytokine |
SMAD2 | SMAD family member 2 | −2.167 | Nucleus | transcription regulator |
TCF7L1 | transcription factor 7-like 1 (T-cell specific, HMG-box) | −2.167 | Nucleus | transcription regulator |
CLDN3 | claudin 3 | −2.029 | Plasma Membrane | transmembrane receptor |
GAB1 | GRB2-associated binding protein 1 | −2.029 | Cytoplasm | other |
HMGA2 | -- | −2.029 | Other | other |
RAF1 | Raf-1 proto-oncogene, serine/threonine kinase | −2.029 | Cytoplasm | kinase |
TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | −2.029 | Nucleus | transcription regulator |
TWIST1 | twist family bHLH transcription factor 1 | −2.029 | Nucleus | transcription regulator |
WNT7B | wingless-type MMTV integration site family, member 7B | −2.029 | Extracellular Space | other |
WNT8B | wingless-type MMTV integration site family, member 8B | −2.029 | Extracellular Space | other |