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Table 3 Ingenuity Pathway Analysis of gene networks

From: Association of aberrant DNA methylation in Apcmin/+ mice with the epithelial-mesenchymal transition and Wnt/β-catenin pathways: genome-wide analysis using MeDIP-seq

Rank Molecules in network Score Focus molecules Top function
1 ↑AMOT,↑ANKRD26,↑CDKN1A,↓CEP152,↓CGGBP1,↓CPA3,↑CPVL, ↓DYNLL2, ↑EID2, ↓ELAC2, ↑EPB41L2, ↑EPB41L3, ↑FRMD6, ↑KIAA0195, ↑MAGEB1, ↑MBNL1, ↑MBNL2, ↑N4BP2L2, ↓NKD2, ↑NSA2, ↑RASSF4, ↓RASSF8, ↑RNF34, ↓SERPINI2, ↑SLC30A5, ↓SLC30A6, ↑SP110, ↑SP140, ↓SPAG5, ↑SYF2, ↓TROAP, ↑TXNDC11, ↑VGLL4, ↑WNT16, ↑WWC1 30 35 Cancer, Cell Cycle, Molecular Transport
2 ↑ACACA, ↓ATRNL1, ↓BHMT, ↑CYP2A13, ↓Cyp2c70, ↑CYP3A43, ↓DCLRE1A, ↑E330013P04Rik, ↓FASN, ↑GPC6, ↑GSTP1, ↓HNMT, ↓IVNS1ABP, ↓Keg1, ↓Lcn4, ↑LRTM1, ↓MC4R, ↓Mill1, ↑MRGPRX3, ↑MT1E, ↑MTF1, ↑NR1H4, ↑RORA, ↑SLC13A1, ↑SLC16A7, ↓SLC29A4, ↓SLC30A1, ↓SLC38A4, ↑SULT1C3, ↓TMC6, ↓UCP1, ↑UPP2, ↓Xlr3c (includes others), ↑ZNF275, ↓ZNF292 30 35 Renal Damage, Renal Tubule Injury, Molecular Transport
3 ↑ABTB2, ↑ALKBH8, ↑ALPK1, ↓BCKDHB, ↑BTBD7, ↑C11orf70, ↑C20orf194, ↑CAMKV, ↓CCDC39, ↑CUL2, ↓CUL3, ↑DCLK2, ↑EGFLAM, ↑FAM98A, ↓FARS2, ↑FBXO10, ↑FBXO34, ↑G2E3, ↓G3BP2, ↑HSP90AA1, ↓KCNG1, ↓KCNS3, ↓KCTD8, ↑KLHL10, ↓KLHL14, ↑KLHL29, ↑KLHL32, ↑KLHL36, ↑KRR1, ↑QDPR, ↑RCBTB1, ↓SEPHS1, ↓UST, ↓YWHAE, ↑ZBED4 30 35 Hereditary Disorder, Respiratory Disease, Metabolic Disease
4 ↓ABCA6, ↓ABLIM3, ↓ABRA, ↑AIF1L, ↓AMBRA1, ↓ARAP2, ↓ARL6, ↓ATL2, ↓CAPN5, ↑CAPN6, ↓CASP12,CD80/CD86, ↑CLEC2D, ↑CLEC6A, ↑CRTAM, ↑GBP5, ↑Gbp8,Gbp6 (includes others), ↑GFM1, ↑GIMAP1-GIMAP5, ↑Gvin1 (includes others), ↑HERC6, ↑IFNG, ↓KIAA0226, ↓KIF16B,↑KLRB1, ↓KMO, ↓KY, ↑LAMP3, ↑LIX1, ↓Neurl3, ↑PCDH17, ↑Phb, ↑PILRB, ↓PMP2 28 34 Endocrine System Disorders, Gastrointestinal Disease, Immunological Disease
5 ↑AFF2, ↑AP4S1, ↑ASAP2, ↓C21orf91, ↑C2orf88, ↑DLGAP1, ↑Eif2s3x, ↓FAM110A, ↑GNS, ↑GRB2, ↑HDGFRP3, ↓KCNH7, ↓KIRREL, ↑KRT83, ↑LRFN4, ↑MEPE, ↑NCK1, ↑NCKAP5, ↓PANX2, ↑PHACTR2, ↑RALGAPA2, ↓RALGPS1, ↑SEPN1, ↑SH2D4A, ↑SHANK2, ↓SHROOM2, ↓SLCO2A1, ↑SNX8, ↑SNX12, ↑SNX18, ↓SPRY, ↑TJAP1, ↑TTYH2, ↑WDR44, ↑ZNF32 28 34 Cellular Assembly and Organization, Tissue Development, Cellular Function and Maintenance
  1. ↑, increased methylation; ↓, decreased methylation