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Table 2 Top 50 annotated genes with decreased methylation

From: Association of aberrant DNA methylation in Apcmin/+ mice with the epithelial-mesenchymal transition and Wnt/β-catenin pathways: genome-wide analysis using MeDIP-seq

Rank

Symbol

Gene name

log2 Fold Change

Location

Type(s)

1

IRX1

iroquois homeobox 1

−5.897

Nucleus

transcription regulator

2

OSBP2

oxysterol binding protein 2

−5.408

Cytoplasm

other

3

CAPN5

calpain 5

−5.231

Cytoplasm

peptidase

4

INTS9

integrator complex subunit 9

−4.837

Nucleus

other

5

TRIML1

tripartite motif family-like 1

−4.837

Other

other

6

CSMD1

CUB and Sushi multiple domains 1

−4.614

Plasma Membrane

other

7

NCOR2

nuclear receptor corepressor 2

−4.272

Nucleus

transcription regulator

8

C6orf89

chromosome 6 open reading frame 89

−4.167

Other

other

9

TMEM242

transmembrane protein 242

−4.167

Other

other

10

DCLRE1A

DNA cross-link repair 1A

−4.100

Nucleus

other

11

EDNRA

endothelin receptor type A

−3.877

Plasma Membrane

transmembrane receptor

12

GALNT11

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)

−3.877

Cytoplasm

enzyme

13

PTPN11

protein tyrosine phosphatase, non-receptor type 11

−3.877

Cytoplasm

phosphatase

14

AGPAT9

1-acylglycerol-3-phosphate O-acyltransferase 9

−3.795

Cytoplasm

enzyme

15

IER5

immediate early response 5

−3.795

Other

other

16

PPM1D

protein phosphatase, Mg2+/Mn2+ dependent, 1D

−3.708

Cytoplasm

phosphatase

17

RBBP6

retinoblastoma binding protein 6

−3.708

Nucleus

enzyme

18

BLOC1S2

biogenesis of lysosomal organelles complex-1, subunit 2

−3.614

Cytoplasm

other

19

CPEB2

cytoplasmic polyadenylation element binding protein 2

−3.614

Cytoplasm

other

20

ECI2

enoyl-CoA delta isomerase 2

−3.614

Cytoplasm

enzyme

21

MMGT1

membrane magnesium transporter 1

−3.614

Cytoplasm

transporter

22

NALCN

sodium leak channel, non-selective

−3.614

Plasma Membrane

ion channel

23

RETNLB

resistin like beta

−3.614

Extracellular Space

other

24

AMD1

adenosylmethionine decarboxylase 1

−3.515

Cytoplasm

enzyme

25

C1orf198

chromosome 1 open reading frame 198

−3.515

Other

other

26

DGKI

diacylglycerol kinase, iota

−3.515

Cytoplasm

kinase

27

DYNLT3

dynein, light chain, Tctex-type 3

−3.515

Cytoplasm

other

28

EPHA6

EPH receptor A6

−3.515

Plasma Membrane

kinase

29

GABRA6

gamma-aminobutyric acid (GABA) A receptor, alpha 6

−3.515

Plasma Membrane

ion channel

30

Gk2

glycerol kinase 2

−3.515

Cytoplasm

other

31

GLT1D1

glycosyltransferase 1 domain containing 1

−3.515

Extracellular Space

enzyme

32

HMGN2

high mobility group nucleosomal binding domain 2

−3.515

Nucleus

other

33

KLHL17

kelch-like family member 17

−3.515

Cytoplasm

other

34

Olfr266

olfactory receptor 266

−3.515

Plasma Membrane

G-protein coupled receptor

35

Ott

ovary testis transcribed

−3.515

Other

other

36

P2RX7

purinergic receptor P2X, ligand-gated ion channel, 7

−3.515

Plasma Membrane

ion channel

37

PTER

phosphotriesterase related

−3.515

Other

enzyme

38

Rnf213

ring finger protein 213

−3.515

Cytoplasm

enzyme

39

SERPINC1

serpin peptidase inhibitor, clade C (antithrombin), member 1

−3.515

Extracellular Space

enzyme

40

TPD52L1

tumor protein D52-like 1

−3.515

Cytoplasm

other

41

ZMAT4

zinc finger, matrin-type 4

−3.515

Nucleus

other

42

RBM20

RNA binding motif protein 20

−3.462

Nucleus

other

43

BEGAIN

brain-enriched guanylate kinase-associated

−3.408

Nucleus

other

44

CHSY3

chondroitin sulfate synthase 3

−3.408

Cytoplasm

enzyme

45

CKAP4

cytoskeleton-associated protein 4

−3.408

Cytoplasm

other

46

DPF3

D4, zinc and double PHD fingers, family 3

−3.408

Other

other

47

Ear2

eosinophil-associated, ribonuclease A family, member 2

−3.408

Cytoplasm

enzyme

48

FAM135B

family with sequence similarity 135, member B

−3.408

Other

enzyme

49

POT1

protection of telomeres 1

−3.408

Nucleus

other

50

POU6F1

POU class 6 homeobox 1

−3.408

Nucleus

transcription regulator