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Table 2 Top 50 annotated genes with decreased methylation

From: Association of aberrant DNA methylation in Apcmin/+ mice with the epithelial-mesenchymal transition and Wnt/β-catenin pathways: genome-wide analysis using MeDIP-seq

Rank Symbol Gene name log2 Fold Change Location Type(s)
1 IRX1 iroquois homeobox 1 −5.897 Nucleus transcription regulator
2 OSBP2 oxysterol binding protein 2 −5.408 Cytoplasm other
3 CAPN5 calpain 5 −5.231 Cytoplasm peptidase
4 INTS9 integrator complex subunit 9 −4.837 Nucleus other
5 TRIML1 tripartite motif family-like 1 −4.837 Other other
6 CSMD1 CUB and Sushi multiple domains 1 −4.614 Plasma Membrane other
7 NCOR2 nuclear receptor corepressor 2 −4.272 Nucleus transcription regulator
8 C6orf89 chromosome 6 open reading frame 89 −4.167 Other other
9 TMEM242 transmembrane protein 242 −4.167 Other other
10 DCLRE1A DNA cross-link repair 1A −4.100 Nucleus other
11 EDNRA endothelin receptor type A −3.877 Plasma Membrane transmembrane receptor
12 GALNT11 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11) −3.877 Cytoplasm enzyme
13 PTPN11 protein tyrosine phosphatase, non-receptor type 11 −3.877 Cytoplasm phosphatase
14 AGPAT9 1-acylglycerol-3-phosphate O-acyltransferase 9 −3.795 Cytoplasm enzyme
15 IER5 immediate early response 5 −3.795 Other other
16 PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D −3.708 Cytoplasm phosphatase
17 RBBP6 retinoblastoma binding protein 6 −3.708 Nucleus enzyme
18 BLOC1S2 biogenesis of lysosomal organelles complex-1, subunit 2 −3.614 Cytoplasm other
19 CPEB2 cytoplasmic polyadenylation element binding protein 2 −3.614 Cytoplasm other
20 ECI2 enoyl-CoA delta isomerase 2 −3.614 Cytoplasm enzyme
21 MMGT1 membrane magnesium transporter 1 −3.614 Cytoplasm transporter
22 NALCN sodium leak channel, non-selective −3.614 Plasma Membrane ion channel
23 RETNLB resistin like beta −3.614 Extracellular Space other
24 AMD1 adenosylmethionine decarboxylase 1 −3.515 Cytoplasm enzyme
25 C1orf198 chromosome 1 open reading frame 198 −3.515 Other other
26 DGKI diacylglycerol kinase, iota −3.515 Cytoplasm kinase
27 DYNLT3 dynein, light chain, Tctex-type 3 −3.515 Cytoplasm other
28 EPHA6 EPH receptor A6 −3.515 Plasma Membrane kinase
29 GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 −3.515 Plasma Membrane ion channel
30 Gk2 glycerol kinase 2 −3.515 Cytoplasm other
31 GLT1D1 glycosyltransferase 1 domain containing 1 −3.515 Extracellular Space enzyme
32 HMGN2 high mobility group nucleosomal binding domain 2 −3.515 Nucleus other
33 KLHL17 kelch-like family member 17 −3.515 Cytoplasm other
34 Olfr266 olfactory receptor 266 −3.515 Plasma Membrane G-protein coupled receptor
35 Ott ovary testis transcribed −3.515 Other other
36 P2RX7 purinergic receptor P2X, ligand-gated ion channel, 7 −3.515 Plasma Membrane ion channel
37 PTER phosphotriesterase related −3.515 Other enzyme
38 Rnf213 ring finger protein 213 −3.515 Cytoplasm enzyme
39 SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 −3.515 Extracellular Space enzyme
40 TPD52L1 tumor protein D52-like 1 −3.515 Cytoplasm other
41 ZMAT4 zinc finger, matrin-type 4 −3.515 Nucleus other
42 RBM20 RNA binding motif protein 20 −3.462 Nucleus other
43 BEGAIN brain-enriched guanylate kinase-associated −3.408 Nucleus other
44 CHSY3 chondroitin sulfate synthase 3 −3.408 Cytoplasm enzyme
45 CKAP4 cytoskeleton-associated protein 4 −3.408 Cytoplasm other
46 DPF3 D4, zinc and double PHD fingers, family 3 −3.408 Other other
47 Ear2 eosinophil-associated, ribonuclease A family, member 2 −3.408 Cytoplasm enzyme
48 FAM135B family with sequence similarity 135, member B −3.408 Other enzyme
49 POT1 protection of telomeres 1 −3.408 Nucleus other
50 POU6F1 POU class 6 homeobox 1 −3.408 Nucleus transcription regulator