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Table 1 Top 50 annotated genes with increased methylation

From: Association of aberrant DNA methylation in Apcmin/+ mice with the epithelial-mesenchymal transition and Wnt/β-catenin pathways: genome-wide analysis using MeDIP-seq

Rank Symbol Gene name log2 Fold Change Location Type(s)
1 ZNF330 zinc finger protein 330 4.614 Nucleus other
2 ACTR3B ARP3 actin-related protein 3 homolog B (yeast) 4.540 Other other
3 CAV3 caveolin 3 4.292 Plasma Membrane enzyme
4 NKX2-3 NK2 homeobox 3 4.199 Nucleus transcription regulator
5 TLN2 talin 2 4.199 Nucleus other
6 CPD carboxypeptidase D 4.100 Extracellular Space peptidase
7 CTNNBL1 catenin, beta like 1 4.100 Nucleus other
8 Vmn2r1 vomeronasal 2, receptor 1 4.100 Plasma Membrane other
9 Cmtm2a CKLF-like MARVEL transmembrane domain containing 2A 3.993 Cytoplasm transcription regulator
10 HPS6 Hermansky-Pudlak syndrome 6 3.993 Cytoplasm other
11 KANK1 KN motif and ankyrin repeat domains 1 3.993 Nucleus transcription regulator
12 RRP1 ribosomal RNA processing 1 3.993 Nucleus other
13 SNX10 sorting nexin 10 3.993 Cytoplasm transporter
14 UNC93A unc-93 homolog A (C. elegans) 3.993 Plasma Membrane other
15 Zfp932 zinc finger protein 932 3.993 Nucleus other
16 ANKRD13D ankyrin repeat domain 13 family, member D 3.877 Plasma Membrane other
17 DACT1 dishevelled-binding antagonist of beta-catenin 1 3.877 Cytoplasm other
18 DMRT2 doublesex and mab-3 related transcription factor 2 3.877 Nucleus other
19 DSC3 desmocollin 3 3.877 Plasma Membrane other
20 LDOC1 leucine zipper, down-regulated in cancer 1 3.877 Nucleus other
21 LRRC8B leucine rich repeat containing 8 family, member B 3.877 Other other
22 SEPP1 selenoprotein P, plasma, 1 3.877 Extracellular Space other
23 SMAD3 SMAD family member 3 3.877 Nucleus transcription regulator
24 Smok2a sperm motility kinase 2B 3.877 Other other
25 TCEAL3 transcription elongation factor A (SII)-like 3 3.877 Other other
26 TNS1 tensin 1 3.877 Plasma Membrane other
27 TRHR thyrotropin-releasing hormone receptor 3.877 Plasma Membrane G-protein coupled receptor
28 WWC1 WW and C2 domain containing 1 3.877 Cytoplasm transcription regulator
29 PER2 period circadian clock 2 3.853 Nucleus other
30 BHLHE23 basic helix-loop-helix family, member e23 3.752 Nucleus transcription regulator
31 GALNT13 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13) 3.752 Cytoplasm enzyme
32 KCNF1 potassium voltage-gated channel, subfamily F, member 1 3.752 Plasma Membrane ion channel
33 MPP1 membrane protein, palmitoylated 1, 55 kDa 3.752 Plasma Membrane kinase
34 OPA1 optic atrophy 1 (autosomal dominant) 3.752 Cytoplasm enzyme
35 PTP4A1 protein tyrosine phosphatase type IVA, member 1 3.752 Cytoplasm phosphatase
36 SGCZ sarcoglycan, zeta 3.752 Plasma Membrane other
37 ADCY7 adenylate cyclase 7 3.614 Plasma Membrane enzyme
38 ALCAM activated leukocyte cell adhesion molecule 3.614 Plasma Membrane other
39 AR androgen receptor 3.614 Nucleus ligand-dependent nuclear receptor
40 C4orf33 chromosome 4 open reading frame 33 3.614 Other other
41 CCNH cyclin H 3.614 Nucleus transcription regulator
42 CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 3.614 Nucleus kinase
43 CDV3 CDV3 homolog (mouse) 3.614 Cytoplasm other
44 COMT catechol-O-methyltransferase 3.614 Cytoplasm enzyme
45 CRYGC crystallin, gamma C 3.614 Cytoplasm other
46 FAM13A family with sequence similarity 13, member A 3.614 Cytoplasm other
47 IGF1R insulin-like growth factor 1 receptor 3.614 Plasma Membrane transmembrane receptor
48 IYD iodotyrosine deiodinase 3.614 Plasma Membrane enzyme
49 JAG1 jagged 1 3.614 Extracellular Space growth factor
50 KCNMA1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 3.614 Plasma Membrane ion channel